kerimistry
LOCATION:
GAINESVILLE, FL
EMPLOYER:
UNIVERSITY OF FLORIDA
Kerim M. Gattás Asfura, Ph.D.
Chemist.
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Member of:
October 17, 2018

Peptide-Coated Quantum Dots

Molecular Recognition / Copper(II)

It was observed that the photoluminescence intensity of cadmium chalcogenides quantum dots (QDs) was altered by some biological relevant metallic ions in aqueous solutions. In particular, copper(II) usually had a significant quenching effect. Hence, standard solid-phase Fmoc-protocol was followed to synthesize Gly-His-Leu-Leu-Cys peptide, which incorporated a Gly-His selective copper(II) binding motif, Leu-Leu hydrophobic segment, and Cys for conjugation with QDs. It was utilized as template for direct synthesis of 2.4 nm CdS QDs toward a more selective fluorometric copper(II) detection system. Micromolar concentrations of copper(II) were detected via photoluminescence quenching. A nanomolar detection limit capability was predicted.

Gattás-Asfura, K. M. and Leblanc, R. M. Chem. Commun. 2003, 2684-2685

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