kerimistry
LOCATION:
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UNIVERSITY OF FLORIDA
Kerim M. Gattás Asfura, Ph.D.
Chemist.
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Member of:
June 19, 2018

Covalently Reinforced Alginate Gels

Scaffolds for Tissue Engineering / Hydrogels

Heterobifunctional linear polyethylene glycol (PEG) was utilized to functionalize alginate’s polymeric backbone with multiple alkyl azide end groups. In the presence of PEG and alginate-based crosslinkers, ionically-crosslinked alginate beads were covalently stabilized via Staudinger ligation. The resulting materials and bioorthogonal covalent stabilization approach were not detrimental to encapsulated mouse insulinoma (MIN6) cells.

Gattás-Asfura, K. M.; Fraker, C. A.; Stabler, C. L. J. Biomed. Mater. Res. Part A 2011, 99A, 47-57

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